Heart of Chicago is part of the Lower West Side, which is Community Area 31 on the the city's official list of 77.

Heart of Chicago is bounded by Blue Island Ave north to 16th St, and Ashland Ave (1600 W) west to Western Ave (2400 W) in ZIP code 60608.

Parts of Heart of Chicago - especially the part east of Damen Ave (2000 W) are often referred to as being in the Pilsen neighborhood.